Specific physiological activity of Australian native fruits

Summary

Selected plant sources: Tasmanian pepper leaf (Tasmanian lanceolata), anise myrtle (Syzygium anisatum), lemon myrtle ( Backhousia citriodora), quandong (Santalum acuminatum) and Davidson’s plum (Davidsonia pruriens) will be evaluated for their genomeprotective and cancer – preventative properties. These sources were identified (project PRJ002330) as superior to the blueberry control with respect to the levels and composition of phytochemicals, and are of significant importance to the industry. The evaluation of genomeprotective activities will be conducted using human cells–based in vitro assays that serve as accelerated models for the detection of specific health properties of phytochemicals. Damage to the genome at the sequence, epigenetic and chromosome level is recognised as the most fundamental cause of infertility, developmental defects, neurogenerative disease, cancer and accelerated aging. The ability of the selected plant sources to reduce genome damage will be assessed using the Cytokinesisblock micronucleus (CBMN) assay. It is expected that the presence of plant bioactives will protect human DNA from the damage. Uptake of bioactives by human cells will be evaluated using the Caco2 cell model system, originally developed to study bioavailability of drugs.

Program

New and Emerging Plant Industries

Research Organisation

CSIRO

Objective Summary

1. Evaluate genomeprotective abilities of selected herbs and fruits 2. Evaluate the ability of plant extracts to suppress the growth of colon, stomach and bladder cancer cells 3. Evaluate differential killing ability for colon and stomach cell model 4. Evaluate bioavailability of compounds using Caco2 cell model system

Project Code

PRJ-004171

Project Stage

Closed

Project Start Date

Tuesday, September 23, 2008

Project Completion Date

Tuesday, August 30, 2011

Journal Articles From Project

Not Available

National Priority

Promoting and maintaining good health

National Priority

Advanced Technology

National Priority

NEPI-Feasibility studies and industry literature reviews

Contact

Related publications

05.03.12

Potential Physiological Activities of Selected Australian Herbs and Fruits