Modulation of gap junction expression in healing equine tendon

Summary

unknown

Program

Thoroughbred Horses

Research Organisation

The University of Queensland

Objective Summary

(1) To quantify differences in gap junction (connexin) protein expression between fibroblasts in normal and injured equine superfical digital flexor tendon (SDFT) tissue. (2) To determine whether targeting the expression of specific connexin protein isoforms by equine tendon fibroblasts can result in upregulation of collagen type I gene expression and protein synthesis. (3) To develop an in vitro model system for investigation of the effects of antisense knockdown of connexin proteins on healing of injured tendon tissue.Hypothesis: "Manipulation of gap junction expression by tenocytes in the injured equine superficial digital flexor tendon can accelerate and improve healing."

Project Code

PRJ-000284

Project Stage

Closed

Project Start Date

Tuesday, May 1, 2007

Project Completion Date

Friday, July 29, 2011

Journal Articles From Project

Not Available

National Priority

Frontier technologies for building and transforming Australian industries

National Priority

Adoption of R&D

National Priority

HOR-Reduce the incidence and impact of diseases and parasites in horses

Contact

Related publications

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Equine Research News - August 2014